Replaces Prod. #: ALX-340-019
Inhibitor of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM).
Product Details
| Alternative Name: | Palmityl trifluoromethylketone, PTK |
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| Formula: | C17H31F3O |
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| MW: | 308.4 |
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| CAS: | 141022-99-3 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, dimethyl formamide or DMSO (warm); sparingly soluble in neutral buffers. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Not stable in basic solutions (pH > 7.4). We do not recommend storing aqueous solutions for more than one day. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A: K. Conde-Friesboes, et al.; JACS 118, 5519 (1996),
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem.
270, 445 (1995),
Abstract;
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