Replaces Prod. #: ALX-270-115
Phospholipase A2 inhibitor (IC50=7 µM for purified guinea pig lung PLA2). Inhibits epinephrine-stimulated thromboxane production in human platelets (86% at 3.5µM). Also blocks insulin secretion in pancreatic islets in response to glucose. Disrupts membrane tubule-mediated reassembly and maintenance of the Golgi complex.
Product Details
| Alternative Name: | 2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid |
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| Formula: | C21H22ClNO3 |
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| MW: | 371.9 |
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| CAS: | 99754-06-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white to yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml, warm) or 100% ethanol (10mg/ml, warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 2 years after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. Do not freeze. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex: R. Abu-Hamdah, et al.; Cell Biol. Int.
28, 7 (2004),
Abstract;
Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists: P. de Figueiredo, et al.; Mol. Biol. Cell
10, 1763 (1999),
Abstract;
Effect of phospholipase A2 inhibitor ONO-RS-082 on substance P-induced histamine release from rat peritoneal mast cells: M. Kurosawa, et al.; Int. Arch. Allergy Immunol.
97, 226 (1992),
Abstract;
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets: R.J. Konrad, et al.; Biochim. Biophys. Acta
1135, 215 (1992),
Abstract;
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H.S. Banga, et al.; PNAS
83, 9197 (1986),
Abstract;
