Replaces Prod. #: ALX-270-172
Diacylglycerol (DAG) is an important cellular source of arachidonate which may be released by the action of DAG lipase. RHC-80267 selectively inhibits DAG lipase activity in canine platelets (IC50=4 µM), bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules.
Product Details
Alternative Name: | U-57908, 1,6-bis-(Cyclohexyloximinocarbonylamino)-hexane |
|
Formula: | C20H34N4O4 |
|
MW: | 394.6 |
|
CAS: | 83654-05-1 |
|
Purity: | ≥98% (HPLC) |
|
Appearance: | White to off-white solid. |
|
MeltingPoint: | 118-121°C |
|
Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
|
Shipping: | Ambient Temperature |
|
Long Term Storage: | Ambient |
|
Use/Stability: | Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation: J. Balsinde, et al.; J. Biol. Chem.
266, 15638 (1991),
Abstract;
Arachidonic acid liberated by diacylglycerol lipase is essential for the release mechanism in chromaffin cells from bovine adrenal medulla: B. Rindlisbacher, et al.; J. Neurochem.
54, 1247 (1990),
Abstract;
Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis: R. Natarajan, et al.; Biochem. Biophys. Res. Commun.
156, 717 (1988),
Abstract;
Inhibitors of diacylglycerol lipase and diacylglycerol kinase inhibit carbamylcholine-stimulated responses in guinea pig pancreatic minilobules: M.C. Sekar & L.E. Hokin; Arch. Biochem. Biophys.
256, 509 (1987),
Abstract;
RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes: S. Levasseur, et al.; Prostaglandins
27, 673 (1984),
Abstract;
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267: C.A. Sutherland & D. Amin; J Biol Chem
257, 14006 (1982),
Abstract;