Product Details
| Alternative Name: | LDL receptor associated protein, LRPAP1, LDL receptor-related protein-associated protein 1 |
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| MW: | ~39kDa (SDS-PAGE) |
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| Source: | Produced in E. coli. |
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| UniProt ID: | P30533 |
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| Formulation: | Liquid. In 0.0067M Phosphate, pH 7.4 containing 0.15M sodium chloride. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Application Notes: | Useful tool for binding studies, and testing in vivo and in cell culture. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
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| Scientific Background: | RAP functions in ER maturation of lipoprotein receptor family members by acting as an antagonist. It blocks binding of PCSK9 to lipoprotein receptors and of all known ligands (including MMP-9 and apoE) to lipoprotein receptor-related protein 1 (LRP-1). Modulates amyloid deposition in mouse models of Alzheimer’s disease. Reduces endocytosis of prion protein (PrPc) by neuronal cells. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources: A. Schmidts, et al.; J. Immunother. Cancer
8, e000990 (2020),
Abstract;
Full Text
The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response: L. Hu, et al.; Redox Biol.
26, 101268 (2019),
Application(s): Treatment of human monocyte-derived macrophages (HMDM) cell cultures,
Abstract;
Full Text
Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts: M. Ryu, et al.; Cell Biol. Int.
41, 1325 (2017),
Application(s): Treatment of primary normal human dermal fibroblasts in cell culture,
Abstract;
