| Alternative Name: | Phosphodiesterase 10A |
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| MW: | 37 kDa |
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| Source: | Produced in E. coli. Active catalytic domain of phosphodiesterase 10A. |
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| UniProt ID: | Q9Y233 |
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| Formulation: | Liquid. In 20mM Tris-HCl, pH 7.5, containing 150mM NaCl, 2mM DTT. |
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| Application Notes: | Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | This enzyme can hydrolyze both cAMP and cGMP, but has a higher affinity for cAMP. In the brain it is present in neuronal cell bodies and neuropil of the striatum, in striatonigral and striatopallidal white matter tracks, and in the substantia nigra and globus pallidus. Outside the brain it is found in the testis, epididymal sperm, and enteric ganglia1. It is under investigation as a drug target for schizophrenia and diabetes. |
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| Regulatory Status: | RUO - Research Use Only |
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