Product Details
| Alternative Name: | Polo-like kinase 1, STPK13, Serine/threonine protein kinase 13 |
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| MW: | 70 kDa |
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| Source: | Produced in insect cells. Full length active PLK1 is fused at the N-terminus to a His-tag. Produced in a baculovirus expression system. |
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| UniProt ID: | P53350 |
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| Application Notes: | Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | PLK localizes to the mitotic spindle and microinjection of PLK into quiescent NIH 3T3 cells induces them to enter mitosis. PLK1 is elevated in many types of cancer and when depleted by siRNA, cell proliferation is inhibited and viability decreased. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy: S. Ruf, et al.; Autophagy
13, 486 (2017),
Abstract;
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