| Alternative Name: | cAMP-dependent protein kinase catalytic subunit α, Protein kinase A C-α |
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| MW: | 69 kDa |
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| Source: | Produced in insect cells. Full length active enzyme fused at the N-terminus to a GST-tag. Produced in a baculovirus expression system. |
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| UniProt ID: | P17612 |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Most of the effects of cAMP in the eukaryotic cell are mediated through the phosphorylation of target proteins on serine or threonine by the cAMP-dependent protein kinase. The inactive cAMP-dependent protein kinase is a tetramer composed of 2 regulatory and 2 catalytic subunits. The cooperative binding of 4 molecules of cAMP dissociates the enzyme in a regulatory subunit dimer and 2 free active catalytic subunits. Null mutations in PKAca leads to early postnatal death in the majority of C-α knock out mice. |
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| Regulatory Status: | RUO - Research Use Only |
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