| Alternative Name: | p70 S6K |
| |
| MW: | 71 kDa |
| |
| Source: | Produced in insect cells. Active, full length p70 S6K. Produced in a baculovirus expression system. |
| |
| UniProt ID: | P23443 (S6K1), Q9UBS0 (S6K2) |
| |
| Formulation: | Liquid. In 50mM sodium phosphate, pH 7.0, containing 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, and 25% glycerol. |
| |
| Application Notes: | Useful for Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening. |
| |
| Shipping: | Dry Ice |
| |
| Long Term Storage: | -80°C |
| |
| Scientific Background: | p70 S6K was first identified as the kinase responsible for the phosphorylation of the S6 ribosomal protein. Research has raised the possibility that S6K might, in fact, be the rapamycin-sensitive effector responsible for directly phosphorylating IRS-1 and thereby inhibiting PI 3-kinase activation. Another study suggests that S6K1 activation may mediate some of the effects of a high-fat diet on inhibiting the insulin-PI 3-kinase signaling pathway3. This makes S6K1 a promising new therapeutic target in the fight against type 2 diabetes. |
| |
| Technical Info/Product Notes: | Replacement for ADI-PPK-439 |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
