Potently increases the efficiency of directed differentiation of mouse and human embryonic stem cells in the presence of Activin A (EC50=0.3µM in Sox17+ /Sox7- cells). Interacts with NME2 and inhibits its nuclear localization leading to downregulation of c-Myc. Under various conditions, stauprimide treated ESC's were able to be differentiated into endoderm, neuronal, and mesoderm cell lines.
Product Details
| Alternative Name: | N-Benzoyl-7-oxostaurosporine |
| |
| Formula: | C35H28N4O5 |
| |
| MW: | 584.6 |
| |
| CAS: | 154589-96-5 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | Yellow solid. |
| |
| Solubility: | Soluble in DMSO (20 mg/ml). |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
A Small Molecule Primes Embryonic Stem Cells for Differentiation: S. Zhu, et al.; Cell Stem Cell
4, 416 (2009),
Abstract;
