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[pSer⁵²]Eukaryotic Initiation factor 2 α polyclonal antibody



BML-SA405-0020	20 µl	184.00 USD

BML-SA405-0100	100 µl	679.00 USD
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Product Details

Alternative Name:	eIF2α

Host:	Rabbit

Immunogen:	Synthetic peptide corresponding to a portion of human eIF2α (eukaryotic initiation factor-2α) phosphorylated at Ser⁵¹(Ser⁵² in mouse).

UniProt ID:	P05198

Species reactivity:	Human, Mouse Yeast

Specificity:	Recognizes human and yeast eIF2α phosphorylated at Ser⁵¹ and mouse eIF2α phosphorylated at Ser⁵².

Crossreactivity:	Does not cross-react with the unphosphorylated form of eIF2α.

Applications:	WB

Recommended Dilutions/Conditions:	Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Formulation:	Liquid. In Dulbecco's PBS, pH 7.3, containing 1mg/ml BSA, 50% glycerol and 0.05% sodium azide.

Handling:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.

Shipping:	Dry Ice

Long Term Storage:	-80°C

Regulatory Status:	RUO - Research Use Only

[pSer52]Eukaryotic Initiation factor 2 alpha polyclonal antibody WB

Mouse 3T3 cell extracts were blotted and incubated with anti-eIF2-α (pS52) antibody following (1) prior incubation in the presence of the peptide immunogen, (2) the nonphosphopeptide corresponding to the eIF2-α (pS51) phosphopeptide, (3) or no peptide. Only the phospho-peptide corresponding to the region surrounding serine 51 (serine 52 in mouse) blocks the antibody signal.

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Product Literature References

Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside: M.J. Virgolini, et al.; Biochim. Biophys. Acta Mol. Cell Res. 1866, 225 (2019), Abstract;