A useful tool for inhibition of cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum. Inhibits cholesterol transport in a variety of cell types such as macrophages and sympathetic neurons. May be used to induce a Neimann-Pick disease type C (NPC)or NPC-like phenotype in a variety of cell types. Inhibits cholesterol biosynthesis at the level of oxido-squalene cyclase (OSC). Induction of cataracts is a common toxic feature of OSC inhibitors such as U18666A.
Product Details
| Alternative Name: | 3β-(2-Diethylaminoethoxy)-Androstenone . HCl |
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| Formula: | C25H41NO2 . HCl |
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| MW: | 424.1 |
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| CAS: | 3039-71-2 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | White solid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Genistein Activates Transcription Factor EB and Corrects Niemann–Pick C Phenotype: G. Argüello, et al.; Int. J. Mol. Sci.
22, 4220 (2021),
Abstract;
Synthesis and Biological Evaluation of Cationic Top-Fluor Cholesterol Analogues: M. Jurášek, et al.; Bioorg. Chem.
117, 105410 (2021),
Abstract;
Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes: N. Heitzig, et al.; Biochim. Biophys. Acta.
1863, 349 (2018),
Abstract;
