| BML-PW1025-0025 | 25 µl | 143.00 USD |  |
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| BML-PW1025-0100 | 100 µl | 470.00 USD | |
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| Alternative Name: | ZMYND9, Zinc finger MYND domain-containing protein 9 |
| Host: | Rabbit |
| Immunogen: | Recombinant fragment of human USP19 (aa 1-129). |
| UniProt ID: | O94966 |
| Source: | Purified from rabbit serum. |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (1:100) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Immunoaffinity purified. |
| Formulation: | Liquid. In 100mM TRIS, pH 7.0 containing 100mM glycine and 0.02% sodium azide. |
| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
| Handling: | Do not freeze. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | The deubiquitinylating enzyme USP19 is induced in skeletal muscle atrophy in response to numerous catabolic stimuli, including cancer, fasting, diabetes, and glucocorticoids. Loss of USP19 interferes with the growth of L6 myoblasts through its modulation of the transcription of major myofibrillar proteins. USP19 regulates cell growth, partly through indirect control of p27Kip1 degradation in the G1 phase of the cell cycle. Since a number of cancers are associated with enhanced degradation of p27Kip1, the overexpression of USP19 may also be a pathogenetic mechanism of the disordered cell growth in cancer and a potential novel therapeutic target for its treatment. In addition USP19 has been shown to be a tail anchored DUB, localised to the ER, suggesting a role in the turnover of ERAD substrates and to be targeted by the unfolded protein response. USP19 is expressed in a wide range of tissues and is localised to the cytoplasm and endoplasmic reticulum. |
| Regulatory Status: | RUO - Research Use Only |
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