Organic vanadium complex which acts as a potent insulin mimic. It normalizes glucose and lipid values and restores food and fluid intake to control levels in diabetic rats without increasing insulin levels (0.37 mmol/kg). It attenuates hyperinsulinemia and hypertension in spontaneously hypertensive rats. Its mechanism of action includes inhibition of PTP1B as well as other tyrosine phosphatases. The drug is nontoxic in vitro at useful concentrations and displays no signs of toxicity in mice at high oral doses.
Product Details
| Alternative Name: | Bis(maltolato)oxovanadium (IV) |
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| Formula: | C12H10O7V |
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| MW: | 317.2 |
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| CAS: | 38213-69-3 |
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| Purity: | ≥96% (TLC) |
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| Appearance: | Black solid. |
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| Solubility: | Soluble in water (10mg/ml) and DMSO (15mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats: C.L. Winter, et al.; Exp. Biol. Med.
230, 207 (2005),
Abstract;
Bis(maltolato)oxovanadium(IV) attenuates hyperinsulinemia and hypertension in spontaneously hypertensive rats: S. Bhanot, et al.; Diabetes
43, 857 (1994),
Abstract;
