Potent and selective leukocyte elastase inhibitor (IC50=44nM). Displays various anti-inflammatory activities including attenuation of LTB4-induced neutrophil migration and serum cytokine levels. Reduces acute inflammatory lung injury in vivo.
Product Details
| Alternative Name: | ONO-5046, N-{2-[({4-[2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt |
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| Formula: | C20H21N2NaO7S . 4H2O |
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| MW: | 528.5 |
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| CAS: | 201677-61-4 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml), ethanol (20mg/ml) or water (2mg/ml, warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB: S. Hagiwara, et al.; Inflamm. Res.
58, 198 (2009),
Abstract;
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1: S. Hagiwara, et al.; Inflammation
31, 227 (2008),
Abstract;
ONO-5046, a novel inhibitor of human neutrophil elastase: K. Kawabata, et al.; Biochem. Biophys. Res. Commun.
177, 814 (1991),
Abstract;
