Irreversible inhibitor of cathepsins B, L, and S, and likely cathepsin H, as well as cruzain and papain. Has been shown to inhibit effector, but not initator, caspases in vitro, and suppress some forms of apoptosis. Has been used in vivo.
Product Details
| Sequence: | Benzyloxycarbonyl-Phe-Ala-fluoromethylketone |
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| MW: | 386.4 |
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| CAS: | 197855-65-5 |
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| Formulation: | Lyophilized |
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| Peptide Content: | ≥95% |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White solid |
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| Solubility: | Soluble in DMSO (10mM) |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Zoonotic Helminth Parasite Fasciola hepatica: Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles: T. Barbour, et al.; Animals
11, 3495 (2021),
Abstract;
