Replaces Prod. #: ALX-260-001
Potent irreversible thrombin inhibitor. Inhibits thrombin activation of progelatinase A. Pretreatment with PPACK inhibits thrombin-induced cerebral thromboembolism in vivo.
Product Details
| Alternative Name: | D-Phe-Pro-Arg-CMK |
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| Sequence: | D-Phe-Pro-Arg-chloromethylketone |
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| Formula: | C21H31ClN6O3 |
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| MW: | 451.0 |
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| CAS: | 71142-71-7 |
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| Purity: | ≥90% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia: D. Li, et al.; Mol. Med. Rep.
23, 449 (2021),
Abstract;
Full Text
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin: L.C. Burzynski, et al.; Immunity
50, 1033 (2019),
Abstract;
Thrombin promotes the expression of Ccnd1 gene in RPE cells through the activation of converging signaling pathways: I. Lee-Rivera, et al. ; Exp. Eye Res.
139, 81 (2015),
Application(s): Thrombin-induced proliferation,
Abstract;
Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis: S. Zucker, et al.; J. Biol. Chem.
270, 23730 (1995),
Abstract;
Markers of coagulation and fibrinolysis in blood drawn into citrate with and without D-Phe-Pro-Arg-Chloromethylketone (PPACK): H.B. Rahr, et al.; Thromb. Res.
73, 279 (1994),
Abstract;
Thrombin inhibitors and anti-coagulants on thrombin-induced embolisation in rabbit cranial vasculature: J.T. Liu, et al.; Eur. J. Pharmacol.
264, 183 (1994),
Abstract;
D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin: C. Kettner & E. Shaw; Thromb. Res.
14, 969 (1979),
Abstract;
