Replaces Prod. #: ALX-270-126
Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll, IC50=0.3nM) in vitro. Potentiates adenosine-stimulated cAMP accumulation.
Product Details
| Alternative Name: | 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-[6,1a]-isoquinolin-4-one . HCl, HL 725 |
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| Formula: | C24H27N3O3 . HCl |
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| MW: | 405.5 . 36.5 |
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| CAS: | 78416-81-6 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR and LC-MS. |
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| Appearance: | White to pale yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml); slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at +20°C. Solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from moisture. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth: R. An, et al.; Am. J. Cancer Res.
9, 1905 (2019),
Abstract;
Full Text
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells: M.E. Whalin, et al.; Mol. Pharmacol.
39, 711 (1991),
Abstract;
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat: F. DeClerck, et al.; Blood Coag. Fibrinol.
1, 247 (1990),
Abstract;
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C- mediated pathways: B.A. Konkle, et al.; J. Biol. Chem.
265, 21867 (1990),
Abstract;
Full Text
HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro: D. Rupert & K.U. Weithmann; Life Sci.
31, 2037 (1982),
Abstract;
