This phosphopeptideis the C-terminal negative regulatory domain of c-Src (521-533) which includes the negative regulatory site (Tyr527). This peptide, when tyrosine-phosphorylated, binds to the internal SH2 domain.
Product Details
| Alternative Name: | [pTyr527] c-Src (521-533) |
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| Sequence: | Ac-Thr-Ser-Thr-Glu-Pro-Gln-pTyr-Gln-Pro-Gly-Glu-Asn-Leu |
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| MW: | 1585.7 |
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| Purity: | ≥98% |
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| Appearance: | Lyophilized solid. |
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| Solubility: | Soluble in Water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis: D. Thompson, et al.; Clin. Sci. (Lond.)
131, 2489 (2017),
Abstract;
Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats: P.K. Picardi, et al.; Endocrinology
149, 3870 (2008),
Abstract;
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Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration: Y. Izawa, et al.; Hypertens. Res.
20, 1107 (2007),
Abstract;
Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4): B. Lu, et al.; J. Biol. Chem.
276, 35589 (2001),
Abstract;
