Pseudosubstrate sequence from PKCα and ß. Highly specific inhibitor, which is N-terminal myristoylated to allow membrane permeability. IC50=8 µM for TPA activation of MARCKS phosphorylation in fibroblast primary cultures, and 98% inhibition at 100 µM. Partially reverses multidrug resistance in human breast cancer cells.
Product Details
| Alternative Name: | PKC (20-28) (myristoylated) |
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| Sequence: | N-Myristoyl-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-OH |
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| MW: | 1256.0 |
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| Formulation: | TFA salt. Lyophilized. |
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| Purity: | ≥98% (HPLC) |
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| Solubility: | Soluble in water or in 20mM TRIS-HCl, pH 7.5. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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