Replaces Prod. #: ALX-151-014
Sequence is from the heat-stable skeletal muscle inhibitor protein of PKA. Peptide binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics protein substrate by binding to the catalytic site via the Arg-cluster basic residues. Ki =2.3 nM for PKA.
Product Details
| Alternative Name: | cAMP-dependent protein kinase inhibitor (5-24) |
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| Sequence: | Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp |
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| Formula: | C94H148N32O31 |
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| MW: | 2222.7 |
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| Source: | Synthetic. |
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| CAS: | 99534-03-9 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid |
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| Solubility: | Soluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase: D. R. Knighton et al.; Science
253, 414 (1991),
Abstract;
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase: H. C. Cheng et al.; J. Biol. Chem.
261, 989 (1986),
Abstract;
