Replaces Prod. #: ALX-152-022
Sequence derived from bovine lung cGMP specific phosphodiesterase (cG-BPDE). Specific substrate for PKG, Km=68 µM; Km for PKA=320 µM, with no phosphorylation detected for CaMKII or PKC.
Product Details
Alternative Name: | cGMP-dependent protein kinase (PKG) substrate |
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Sequence: | H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH |
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Formula: | C68H115N23O20 |
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MW: | 1574.8 |
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Source: | Synthetic. |
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Formulation: | Lyophilized. |
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Purity: | ≥97% (HPLC) |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in water. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries: R.B. Thorpe, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol.
304, R734 (2013),
Abstract;
Full Text
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases: J.L. Colbran, et al.; J. Biol. Chem.
267, 9589 (1992),
Abstract;
Full Text
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase: J.D Corbin & S.O. Døskeland; J. Biol. Chem.
258, 11391 (1983),
Abstract;
Full Text