Replaces Prod. #: ALX-550-344
Glutamate release inhibitor. Neuroprotective. Blocks the inactivated state of voltage-gated neuronal Na+ channels at very low concentrations (about 0.1µM) and activates the TREK family of two-pore domain potassium channels.
Product Details
| Alternative Name: | 2-Amino-6-(trifluoromethoxy)-benzothiazole, 6-(Trifluoromethoxy)-2-benzothiazolamine |
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| Formula: | C8H5F3N2OS |
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| MW: | 234.2 |
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| CAS: | 1744-22-5 |
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| MI: | 14: 8223 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml), methanol (>40mg/ml), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (14mg/ml) or in 0.1N HCl (11mg/ml); insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for up to 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Do sodium channel blockers have neuroprotective effect after onset of ischemic insult?: O. Ates, et al.; Neurol. Res.
29, 317 (2007),
Abstract;
Therapeutic potential of neuronal two-pore domain potassium-channel modulators: A. Mathie & E.L. Veale; Curr. Opin. Investig. Drugs
8, 555 (2007),
Abstract;
Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels: J.H. Song, et al.; J. Pharmacol. Exp. Ther.
282, 707 (1997),
Abstract;
Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats: M.C. Guyot, et al.; Neuroscience
81, 141 (1997),
Abstract;
Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurons: M. Umemiya & A.J. Berger; Br. J. Pharmacol.
116, 3227 (1995),
Abstract;
Na+ channels as targets for neuroprotective drugs: C.P. Taylor & B.S. Meldrum; TIPS
16, 309 (1995), (Review),
Abstract;
Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures: A.G. Estevez, et al.; Eur. J. Pharmacol.
280, 47 (1995),
Abstract;
Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study: A. Benazzouz, et al.; Eur. J. Pharmacol.
284, 299 (1995),
Abstract;
Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission: J. Mantz, et al.; Anesthesiology
76, 844 (1992),
Abstract;
Effects of riluzole (2-amino-6-trifluoromethoxy benzothiazole) on striatal neurochemical markers in the rat, with special reference to the dopamine, choline, GABA and glutamate synaptosomal high affin: D. Samuel, et al.; Fundam. Clin. Pharmacol.
6, 177 (1992),
Abstract;
Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia: J. Pratt, et al.; Neurosci. Lett.
140, 225 (1992),
Abstract;
