Replaces Prod. #: ALX-550-252
Quaternary derivative of lidocaine (Prod. No. ALX-550-251). Blocks voltage-gated Na+ channels. Effectively blocks cardiac Na+ channels when applied from either side of the membrane but blocks neuronal Na+channels only from the intracellular side. Externally applied QX-314 was shown to inhibit high frequency activity in sensory nerves
Product Details
| Formula: | C16H27BrN2O |
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| MW: | 343.3 |
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| CAS: | 21306-56-9 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
QX-314 Induces Analgesia to Nociceptive Thermal Stimulus by Co-Application with Capsiate or Anandamide: H. Nakagawa, et al.; Austin Biomark. Diagn.
1, 1 (2014),
Application(s): Injection,
Full Text
Local anesthetic block of batrachotoxin-resistant muscle Na+ channels: G.K. Wang, et al.; Mol. Pharmacol.
54, 389 (1998),
Abstract;
QX-314 inhibits ectopic nerve activity associated with neuropathic pain: I. Omana-Zapata, et al.; Brain Res.
771, 228 (1997),
Abstract;
Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel: Y. Qu, et al.; PNAS
92, 11839 (1995),
Abstract;
Interactions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gating: J.Z. Yeh & G.S. Oxford; J. Gen. Physiol.
85, 603 (1985),
Abstract;
Effects of local anesthetic QX-314 on the membrane properties of hippocampal pyramidal neurons: B.W. Connors & D.A. Prince; J. Pharmacol. Exp. Ther.
220, 476 (1982),
Abstract;
