A mitogenic lipid phosphate produced via the action of phospholipase D. Mediates agonist-dependent Raf-1 translocation and activation of the MAP kinase cascade. Activates PKCζ.
Product Details
| Alternative Name: | 1,2-Dioleoyl-sn-glycero-3-phosphate . Na |
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| Formula: | C39H73O8P . Na |
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| MW: | 724 |
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| CAS: | 108392-02-5 |
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| Purity: | ≥98% (GC) |
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| Identity: | Determined by IR. |
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| Appearance: | White powder. |
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| Solubility: | Soluble in chloroform. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras: M. A. Rizzo, et al.; J. Biol. Chem.
275, 23911 (2000),
Abstract;
Full Text
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway: M. A. Rizzo, et al.; J. Biol. Chem.
274, 1131 (1999),
Abstract;
A role for phospholipase D in control of mitogenesis: M. R. Boarder, et al.; Trends Pharmacol Sci.
15, 57 (1994),
Abstract;
Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids: C. Limatola; Biochem. J.
304, 1001 (1994),
Abstract;
