Replaces Prod. #: ALX-300-045
A mitogenic lipid phosphate produced via the action of phospholipase D. Mediates agonist-dependent Raf-1 translocation and activation of the MAP kinase cascade.
Product Details
| Alternative Name: | 1,2-Dipalmitoyl-sn-glycero-3-phosphate . sodium salt, DPPA |
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| Formula: | C35H68O8P·Na |
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| MW: | 670.9 |
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| CAS: | 169051-60-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Fine suspension in ethanol (5mg/ml) with 15 minutes of sonication at room temperature. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phosphatidic acid homeostasis regulated by a type-2 phosphatidic acid phosphatase represents a novel druggable target in malaria intervention: R. Kumar Sah, et al.; Cell Death Dis.
5, 107 (2019),
Abstract;
Full Text
The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras: M.A. Rizzo, et al.; J. Biol. Chem.
275, 23911 (2000),
Abstract;
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway: M.A. Rizzo, et al.; J. Biol. Chem.
274, 1131 (1999),
Abstract;
A role for phospholipase D in control of mitogenesis: M.R. Boarder; Trends Pharmacol. Sci.
15, 57 (1994),
Abstract;
