Replaces Prod. #: ALX-301-001
Platelet activating factor (PAF) with a C16 alkyl group. Initiates receptor-mediated responses in platelets and a variety of other cells. Rabbit platelet PAF receptor KD=0.1 nM. EC50 for stimulation of phosphoinositide metabolism in hippocampal cell line: 1.2-1.5 nM.
Product Details
| Alternative Name: | PAF C-16 |
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| Formula: | C26H54NO7P |
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| MW: | 523.7 |
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| CAS: | 74389-68-7 |
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| MI: | 14: 7524 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in 100% ethanol (>100 mg/ml). Soluble in water (>100mg/ml) after sonication for 1 minute at 40°C. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 2 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Biotinylated heptapeptides substituted with a d-amino acid as platelet-activating factor inhibitors: A. Sato, et al.; Eur. J. Pharmacol.
764, 202 (2015),
Application(s): Injection into rat hind paw, Spectroscopy,
Abstract;
Blood cardiolipin in haemodialysis patients. Its implication in the biological action of platelet-activating factor: S. Antonopoulou, et al.; Int. J. Biochem. Cell Biol.
28, 43 (1996),
Abstract;
Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells: L.C. Shi, et al.; J. Neurochem.
67, 1478 (1996),
Abstract;
