TRAM-34 is a potent and selective inhibitor of the intermediate-conductance Ca2+-activated potassium channel (IKCa). It displays immunosuppressive activity and inhibits the proliferation of endometrial cancer cells.
Product Details
| Alternative Name: | 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole |
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| Formula: | C22H17ClN2 |
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| MW: | 344.8 |
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| CAS: | 289905-88-0 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Pale yellow solid. |
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| Solubility: | Soluble in DMSO (10 mg/mL at 40°C) or ethanol (6 mg/mL at 40°C). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Fatty Acid and Related Potassium Kv2 Channel Blockers: Toxicity and Physiological Actions on Mosquitoes: F. Demares, et al.; Insects
9, 155 (2018),
Abstract;
Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer: Z. H. Wang, et al.; Oncogene
26, 5107 (2007),
Abstract;
K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression: G. Panyi, et al.; Curr. Pharm. Des.
12, 2199 (2006),
Abstract;
K+ channels as targets for specific immunomodulation: K. G. Chandy, et al.; Trends Pharmacol. Sci.
25, 280 (2004),
Abstract;
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Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant: H. Wulff, et al.; Proc. Natl. Acad. Sci. USA
97, 8151 (2000),
Abstract;
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