Replaces Prod. #: ALX-630-020
Fungal mycotoxin. Selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ (maxi-K) channel (100% block at 10 nM). Increases spontaneous release of GABA and aspartate from cerebrocortical synaptosomes in rat neuromuscular junction.
Product Details
| Alternative Name: | NSC 354845, Tremortin A |
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| Formula: | C37H44ClNO6 |
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| MW: | 634.2 |
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| CAS: | 12627-35-9 |
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| RTECS: | RY7535000 |
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| Purity: | ≥95% (HPLC, TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in organic solvents such as methanol, acetone or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chlorinated flavonoids modulate the inflammatory process in human blood: C. Proença, et al.; Inflammation.
40, 1155 (2017),
Abstract;
The cyclooctadepsipeptide anthelmintic emodepside differentially modulates nematode, insect and human calcium-activated potassium (SLO) channel alpha subunits: A. Crisford, et al.; PLoS Negl. Trop. Dis.
9, e0004062 (2015),
Abstract;
Full Text
Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study: P. Breton, et al.; Toxicon
36, 645 (1998),
Abstract;
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels: H.G. Knaus, et al.; Biochemistry
33, 5819 (1994),
Abstract;
Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations: B.J. Wilson, et al.; Brain Res.
40, 540 (1972),
Abstract;
