Replaces Prod. #: ALX-630-019
Paxilline is an indole alkaloid isolated from Penicillium paxilli. It is a selective and reversible blocker of the smooth muscle high conductance Ca2+-activated K+ (maxi-K) channel (70% block at 10 nM). In neutrophils, Paxilline blockage of BKCa channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. Inhibitor of the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.
Product Details
| Formula: | C27H33NO4 |
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| MW: | 435.6 |
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| CAS: | 57186-25-1 |
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| RTECS: | DJ2830000 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The mycotoxin paxilline inhibits the cerebellar inositol 1,4, 5-trisphosphate receptor: C.L. Longland, et al.; Eur. J. Pharmacol.
408, 219 (2000),
Abstract;
Effects of channel modulators on cloned large-conductance calcium-activated potassium channels: V.K. Gribkoff, et al.; Mol. Pharmacol.
50, 206 (1996),
Abstract;
Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel: M. Sanchez & O.B. McManus; Neuropharmacology
35, 963 (1996),
Abstract;
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels: H.G. Knaus, et al.; Biochemistry
33, 5819 (1994),
Abstract;
Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel: J. Vazquez, et al.; J. Biol. Chem.
265, 15564 (1990),
Abstract;
A new tremorgenic metabolite from Penicillium paxilli: R.J. Cole, et al.; Can. J. Microbiol.
20, 1159 (1974),
Abstract;
