A selective RARα antagonist (concentration required to inhibit 50% of specific retinoic acid binding: RARα, 60 nM; RARß, 2400 nM; RARτ, 3300 nM). Counteracts the effects of retinoic acid on HL-60 cell differentiation, B-lymphocyte polyclonal activation and in a RARα transactivation assay. Ro 41-5253 suppresses retinoic acid-induced connexin 43 protein expression in 10T1/2 cells.
Product Details
| Formula: | C28H36O5S |
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| MW: | 484.7 |
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| CAS: | 144092-31-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (50mg/ml) or 100% ethanol (15mg/ml, warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Involvement of hedgehog signaling in all-trans retinoic acid-mediated suppression of colon cancer: Y. Xu, et al.; Am. J. Transl. Res.
14, 6536 (2022),
Abstract;
Detection of retinoic acid receptor antagonist contamination in the aquatic environment of the Kinki region of Japan: D. Inoue, et al.; Water Res.
103, 58 (2016),
Application(s): RAR antagonistic activity assay,
Abstract;
Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn's disease: N.E. McCarthy, et al.; J. Clin. Invest.
125, 3215 (2015),
Application(s): Cell Culture,
Abstract;
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Cancer prevention by retinoids and carotenoids: independent action on a common target: J. S. Bertram; Biochim. Biophys. Acta.
1740, 170 (2005),
Abstract;
Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping: S. Keidel et al.; Mol. Cell. Biol.
14, 287 (1994),
Abstract;
