Replaces Prod. #: ALX-430-104
HMG-CoA reductase inhibitor. Synthetic analog of Lovastatin (Prod. No. BML-G226). Inhibits the biosynthesis of isoprenoids and prevents small G protein activation. Displays lipid lowering and antihypertensive effects. Displays antiinflammatory, immunomodulatory effects as well as protective effects in experimental traumatic brain injury. Activates Rac1-dependent signalling pathway.
Product Details
| Formula: | C25H38O5 |
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| MW: | 418.6 |
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| CAS: | 79902-63-9 |
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| MI: | 14: 8539 |
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| RTECS: | EK7798000 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml); insoluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Polycaprolactone-collagen nanofibers loaded with dexamethasone and simvastatin as an osteoinductive and immunocompatible scaffold for bone regeneration applications: H.A. Rather, et al.; Biomater. Biosyst.
8, 100064 (2022),
Abstract;
Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer’s disease: X.K. Tong, et al.; Cell Death Dis.
13, 325 (2022),
Abstract;
Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation: L. Voss, et al.; Pharmaceuticals (Basel)
14, 727 (2021),
Abstract;
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters: M. Mehibel, et al.; Sci. Rep.
8, 16804 (2018),
Abstract;
Full Text
Simvastatin prevents β-amyloid 25-35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate: C. Wang, et al.; Neuropharmacology
97, 122 (2015),
Application(s): Oral administration to male mice,
Abstract;
Beyond lipid lowering: the anti-hypertensive role of statins: V. Chopra, et al.; Cardiovasc. Drugs Ther.
21, 161 (2007),
Abstract;
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury: H. Wang, et al.; Exp. Neurol.
206, 59 (2007),
Abstract;
HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation: H. Xu, et al.; Am. J. Physiol. Renal Physiol.
291, F995 (2006),
Abstract;
Anti-inflammatory and immunomodulatory effects of statins: L.M. Blanco-Colio, et al.; Kidney Int.
63, 12 (2003),
Abstract;
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy: F.R. Danesh, et al.; Proc Natl Acad Sci USA
99, 8301 (2002),
Abstract;
Lovastatin and simvastatin are modulators of the proteasome: C. Wojcik, et al.; Int. J. Biochem. Cell Biol.
32, 957 (2000),
Abstract;
