Replaces Prod. #: ALX-290-009
Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=30 nM) and in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=35.8 µM and 67 µM respectively). α-Hydroxyfarnesylphosphonic acid inhibited (1 µM) Ras processing in Ha-ras-transformed NIH 3T3 fibroblasts.
Product Details
| Formula: | C15H27O4P |
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| MW: | 302.4 |
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| Source: | Synthetic. |
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| CAS: | 140633-12-1 |
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| Concentration: | 2 mg/ml |
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| Formulation: | Solution in ethanol. |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Liquid. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. |
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| Handling: | Do not evaporate to dryness. Compound decomposes out of solution. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of Ras farnesyltransferases: F. Tamanoi; Trends Biochem. Sci.
18, 349 (1993),
Abstract;
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo: J.B. Gibbs, et al.; J. Biol. Chem.
268, 7617 (1993),
Abstract;
Steady-state kinetic mechanism of Ras farnesyl:protein transferase: D.L. Pompliano, et al.; Biochemistry
31, 3800 (1992),
Abstract;
