Replaces Prod. #: ALX-270-265
Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant. Inhibits lipid peroxidation in a variety of experimental systems including cultured brain microvessel endothlial cells, Cu2+ treated monocyclic THP1 cells and LLC-PK1 cell layers where it blocks F2 isoprostane production. Prevented organ damage in intestinal cold storage, preservation and reperfusion injury.
Product Details
| Alternative Name: | 21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate |
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| Formula: | C37H50N6O2 . C4H4O4 |
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| MW: | 726.9 |
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| CAS: | 153190-29-5 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml). Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
UPLC-MS/MS Assay of 21-Aminosteroid (Lazaroid U74389G) for Application in Pharmacokinetic Study: P. Gadgil, et al.; J. Pharm. Biomed. Anal.
122, 90 (2016),
Application(s): UPLC-MS/MS assay of lazaroid in rat plasma,
Abstract;
Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice: K. Fukuma, et al.; Surgery
125, 421 (1999),
Abstract;
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia: R. Schmid-Elsaesser, et al.; Brain Res.
816, 471 (1999),
Abstract;
Full Text
The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock:: D. Altavilla, et al.; Eur. J. Pharmacol.
369, 49 (1999),
Abstract;
Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats: D. Melchiorri, et al.; Life Sci.
62, 1927 (1998),
Abstract;
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals: A. Khalil, et al.; Life Sci.
63, 769 (1998),
Abstract;
Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389: S. Awasthi, et al.; Toxicol. Lett.
95, 47 (1998),
Abstract;
The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain: R.H. Fabian, et al.; J. Neurotrauma
15, 433 (1998),
Abstract;
Comparison of various lazaroid compounds for protection against ischemic liver injury: N. Ishizaki, et al.; Transplantation
63, 202 (1997),
Abstract;
Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation: G.M. Campo, et al.; J. Pharmacol. Exp. Ther.
277, 333 (1996),
Abstract;
Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G: A.M. Perna, et al.; Pharmacol. Res.
34, 25 (1996),
Abstract;
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers: F. Shi, et al.; Free Radic. Biol. Med.
19, 349 (1995),
Abstract;
Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants: D.J. Crutchley & B.G. Que; Circulation
92, 238 (1995),
Abstract;
Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol.
6, 1300 (1995),
Abstract;
Improved small intestinal preservation after lazaroid U74389G treatment and cold storage in University of Wisconsin solution: S.M. Katz, et al.; Transplantation
59, 694 (1995),
Abstract;
