Replaces Prod. #: ALX-300-138
Major mono-unsaturated fatty acid constituent of olive oil occurring as the glyceride. Activates protein kinase C (PKC) in hepatocytes. Inhibitor of glucose production and food intake. Upregulates the expression of uncoupling protein-3 (UCP-3) in L6 myotubes. Promotes differentiation of cultured neuronal cells mediated via PPARβ and it induces a myofibroblast-like phenotype in mesangial cells.
Product Details
| Alternative Name: | cis-9-Octadecenoic acid 18:1 |
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| Formula: | C18H34O2 |
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| MW: | 282.5 |
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| CAS: | 112-80-1 |
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| MI: | 14: 6828 |
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| Purity: | ≥99% (GC) |
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| Appearance: | Colorless oil/low-melting solid. |
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| Solubility: | Soluble in 100% ethanol (>25mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C under inert gas. |
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| Handling: | Protect from light and oxygen. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro: S.F. Petry, et al.; Antioxidants
11, 788 (2022),
Abstract;
Oleate induces a myofibroblast-like phenotype in mesangial cells: R. Mishra & M.S. Simonson; Arterioscler. Thromb. Vasc. Biol.
28, 541 (2008),
Abstract;
Active components and clinical applications of olive oil: E. Waterman & B. Lockwood; Altern. Med. Rev.
12, 331 (2007),
Abstract;
PPARbeta agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y: S. Di Loreto, et al.; J. Cell Physiol.
211, 837 (2007),
Abstract;
Effects of rosiglitazone and oleic acid on UCP-3 expression in L6 myotubes: A. Costello, et al.; Diabetes Obes. Metab.
5, 136 (2003),
Abstract;
Central administration of oleic acid inhibits glucose production and food intake: S. Obici, et al.; Diabetes
51, 271 (2002),
Abstract;
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Chronic feline leukemia virus infection alters arachidonic acid proportions in vivo and in vitro: L.L. Williams, et al.; Proc. Soc. Exp. Biol. Med.
202, 239 (1993),
Abstract;
Free fatty acid-induced alterations in the steroid-binding properties of rat androgen-binding protein: F. Felden, et al.; BBRC
190, 602 (1993),
Abstract;
Spinal cord of the rat contains more lipoprotein lipase than other brain regions: D.H. Bessesen, et al.; J. Lipid Res.
34, 229 (1993),
Abstract;
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes: M.J. Diaz-Guerra; J. Biol. Chem.
266, 23568 (1991),
Abstract;
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