Novel inhibitor of ubiquitin C-terminal hydrolase L1 (IC50 = 0.81 µM). It displays 21-fold greater selectivity over UCH-L3 (IC50 = 17 µM).
Product Details
| Alternative Name: | N-(3,4-Dichlorobenzyl)-5-bromoisatin O-acetyloxime |
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| Formula: | C17H11BrCl2N2O3 |
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| MW: | 442.1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (5mg/ml with warming) or dimethyl formamide (10mg/ml with warming). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month. |
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| Handling: | Store tightly sealed. Allow product to equilibrate to room temperature prior to opening. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mechanisms, biology and inhibitors of deubiquitinating enzymes: K.R. Love, et al.; Nat. Chem. Biol.
3, 697 (2007),
Abstract;
