Replaces Prod. #: ALX-270-477
STO-609 is a specific CaM kinase kinase (CaM-KK) inhibitor. Ki=0.2μM and 0.04μM for α and β isotypes respectively. Demonstrates >80-fold selectivity for CAM-KK over CaMK1, CaMK2, CaMK4, MLCK, PKA, PKC, and p42 MAPK. Concentrations up to 10μg/ml do not affect cellular viability. It is a tool for exploring the role of the CaM-KK pathway in various physiological processes.
Product Details
| Alternative Name: | 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt |
| |
| Formula: | C19H10N2O3·C2H4O2 |
| |
| MW: | 374.3 |
| |
| CAS: | 1173022-21-3 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | Yellow solid. |
| |
| Solubility: | Soluble in DMSO (10mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | Ambient |
| |
| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol.
321, C549 (2021),
Abstract;
Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels: S.V. Jabba, et al.; J. Pharmacol. Exp. Ther.
332, 698 (2010),
Abstract;
Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle: N. Iwanaka, et al.; J. Appl. Physiol.
108, 274 (2010),
Abstract;
STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase: H. Tokumitsu, et al.; J. Biol. Chem.
277, 15813 (2002),
Abstract;
