Potent and selective inhibitor of the kinase activity of the human vascular endothelial growth factor receptor 2 (VEGFR2/KDR). Selectively inhibits VEGFR2 over VEGFR1 and other receptor tyrosine kinases with an IC50 = 2nM. Useful tool for exploring the biology of VEGFR receptors.
Product Details
| Alternative Name: | 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methyl phenol |
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| Formula: | C22H18FN3O2 |
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| MW: | 375.4 |
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| Source: | Synthetic. |
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| CAS: | 193001-14-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (3 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for 1 year as supplied. Stock solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity , probably through VEGF receptor 1 in vivo.: C.A. Glass, et al.; J. Physiol.
572, 243 (2006),
Abstract;
Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF: A. Endo, et al.; J. Recept. Signal Transduct. Res.
23, 239 (2003),
Abstract;
ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity: C.E. Whittles, et al.; Microcirculation
9, 513 (2002),
Abstract;
