Inhibitor of NF-κB which displays potent inhibitory effects on both NF-κB transcriptional activation (IC50=11nM) and TNF-α production (IC50= 7nM). A useful tool to explore the role of NF-κB in cellular signaling pathways.
Product Details
| Formula: | C22H20N4O |
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| MW: | 356.4 |
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| CAS: | 545380-34-5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (20 mg/ml); DMF (30mg/ml); 100% ethanol (10 mg/ml); not soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells: S. Choi, et al.; J. Biol. Chem.
281, 12722 (2006),
Abstract;
A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives: M. Tobe, et al.; Bioorg. Med. Chem.
11, 3869 (2003),
Abstract;
