Replaces Prod. #: ALX-270-402
Hypolipidemic agent. Potent, reversible and competitive inhibitor of acetyl-coenzyme A carboxylase (Ac-CoA carboxylase; ACC), a key enzyme involved in fatty acid biosynthesis. It blocks apoptosis induced by the fatty acid synthase inhibitor C75 (Prod. No. ALX-270-286) and stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.
Product Details
| Alternative Name: | 5-(Tetradecyloxy)-2-furoic acid, RMI-14514 |
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| Formula: | C19H32O4 |
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| MW: | 324.5 |
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| CAS: | 54857-86-2 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | Off-white solid. |
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| MeltingPoint: | 108-110°C |
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| Solubility: | Soluble in dimethyl formamide, DMSO (10mg/ml), 100% ethanol or methanol. Sparingly soluble in aqueous buffers. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools: P.K. Morgan, et al.; J. Biol. Chem.
297, 101341 (2021),
Abstract;
Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function: J. K. Gardner, et al.; PLoS One
10, e0123563 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem.
279, 3817 (2004),
Abstract;
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells: W. Zhou, et al.; Cancer Res.
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Abstract;
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts: E.S. Pizer, et al.; Cancer Res.
60, 213 (2000),
Abstract;
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors: T.M. Loftus, et al.; Science
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Abstract;
Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family: A. Schmidt, et al.; Mol. Cell. Endocrinol.
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Abstract;
Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster: C.M. Arbeeny, et al.; J. Lipid Res.
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Abstract;
Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid: D.L. Halvorson & S.A. McCune; Lipids
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Abstract;
Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver: N. Fukuda and J.A. Ontko; J. Lipid Res.
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Abstract;
5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids: R.A. Parker, et al.; J. Med. Chem.
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General Literature References
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase: C. Forest, et al.; Biochem. Soc.
31, 1125 (2003),
Abstract;
Hypothalamic malonyl-CoA as a mediator of feeding behavior: Z. Hu, et al.; PNAS
100, 12624 (2003),
Abstract;
Mechanistic diversity and regulation of Type II fatty acid synthesis: H. Marrakchi, et al; Biochem. Soc. Trans.
30, 1050 (2002),
Abstract;
