TMP-153 is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals.
Product Details
| Formula: | C24H18ClF2N3O |
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| MW: | 437.9 |
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| CAS: | 128831-46-9 |
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| Purity: | ≥98% |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or ethanol (10mg/ml with warming). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome: N.D. Vaziri, et al.; Circulation
110, 419 (2004),
Abstract;
Full Text
TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters: Y. Sugiyama, et al.; Atherosclerosis
113, 71 (1995),
Abstract;
TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in golden hamsters: Y. Sugiyama, et al.; Atherosclerosis
118, 145 (1995),
Abstract;
