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Ro 31-8220

PKC inhibitor



BML-EI283-0001	1 mg	115.00 USD
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Replaces Prod. #: ALX-270-020

Cell-permeable PKC inhibitor. Selective for PKC (IC₅₀=10nM) over CaM kinase II (IC₅₀=17µM) and PKA (IC₅₀=0.9µM). Induces apoptosis in various cell lines.

Product Details

Alternative Name:	2-[1-(3-(Amidinothio)propyl)-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide·methanesulfonate, Bisindolylmaleimide IX . Methanesulfonate

Formula:	C₂₅H₂₃N₅O₂S·CH₄O₃S

MW:	553.7

CAS:	138489-18-6

Purity:	≥98%

Appearance:	Red/orange solid.

Solubility:	Soluble in DMSO (10mg/ml)

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

The rapid activation of cPKCβII by progesterone results in the negative regulation of Ca 2+ influx in human resting T cells: V.H.C. Lin, et al.; J. Chin. Med. Assoc. (2023), Abstract;

Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3.: L. Shen & R.I. Glazer; Biochem. Pharmacol. 55, 1711 (1998), Abstract;

Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors.: T.E. Harris et al.; Biochem. Biophys. Res. Commun. 227, 672 (1996), Abstract;

Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.: J. Budworth & A. Gescher; FEBS Lett. 362, 139 (1995), Abstract;

Characterisation of protein kinase C isoforms and enzymic activity from the alpha T3-1 gonadotroph-derived cell line.: M.S. Johnson et al.; FEBS Lett. 333, 67 (1993), Abstract;

Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells.: J.P. McKenna & P.J. Hanson; Biochem. Pharmacol. 46, 583 (1993), Abstract;

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.: S.E. Wilkinson et al.; Biochem. J. 294, 335 (1993), Abstract;