Replaces Prod. #: ALX-270-219
Inhibitor of cytokine induced IκBα phosphorylation resulting thereby in a decreased expression of NF-κB and adhesion molecules. Potential anti-inflammatory agent.
Product Details
| Alternative Name: | (E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile |
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| Formula: | C10H9NO2S |
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| MW: | 207.2 |
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| CAS: | 19542-67-7 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO, 100% ethanol, methanol or methylene dichloride; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
TNF-α and NF-κB signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy: V. Wang, et al.; PLoS One
17, e0271950 (2022),
Abstract;
Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils: I. Demirel, et al.; Sci. Rep.
10, 21837 (2020),
Abstract;
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Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways: W. Huang, et al.; Mediators Inflamm.
2020, 9421340 (2020),
Abstract;
Full Text
Effect of Glutamate on Brain Iron Metabolism and the Regulation Mechanism: P. Yu, et al.; J. Drug Metab. Toxicol.
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Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages: D.K. Lee, et al.; FEBS Lett.
589, 2859 (2015),
Application(s): Cell Culture,
Abstract;
Sterile-filtered saliva is a strong inducer of IL-6 and IL-8 in oral fibroblasts: B. Cvikl, et al.; Clin. Oral. Investig.
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Application(s): Treatment of fibroblasts in culture,
Abstract;
TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer: J.B. Jeong, et al.; Int. J. Mol. Sci.
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Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death: T.M. Kauppinen & R.A. Swanson; J. Immunol.
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Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience
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Abstract;
Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells: S.A. Keller, et al.; Blood
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Abstract;
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha- induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways: M.M. Remacle-Bonnet, et al.; Cancer Res.
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Abstract;
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor- kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis: F. Thevenod, et al.; J. Biol. Chem.
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Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem.
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