Replaces Prod. #: ALX-270-148
RG-13022 is a non-phenolic tyrphostin analog, which inhibits the EGF receptor (IC50=5 µM) and PDGF receptor tyrosine kinases, and is long-acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=1 µM) as well as tumor growth in vivo. It inhibits both EGF- and PDGF-stimulated DNA synthesis in human glioma cell lines. RG-13022 is non-phenolic and therefore possesses less antioxidant activity than other tyrphostins.
Product Details
| Alternative Name: | 3,4-Dimethoxy-α-(3-pyridyl)-(Z)-cinnamonitrile |
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| Formula: | C16H14N2O2 |
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| MW: | 266.3 |
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| CAS: | 136831-48-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble at 25mg/ml in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months. |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of protein tyrosine phosphorylation reduce the proliferation of two human glioma cell lines: P.A. Oude Weernink, et al.; Neurosurgery
38, 108 (1996),
Abstract;
The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice: T. Yoneda, et al.; Cancer Res.
51, 4430 (1991),
Abstract;
