Replaces Prod. #: ALX-270-129
A potent inhibitor of EGF receptor kinase activity (IC50=35 µM).
Product Details
| Alternative Name: | α-Cyano-(3,4-dihydroxy)cinnamonitrile |
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| Formula: | C10H6N2O2 |
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| MW: | 186.1 |
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| CAS: | 118409-57-7 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | Yellow-tan solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Product is subject to oxidation. |
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| Handling: | Store tightly sealed in the dark. Protect from light. Make solutions fresh daily. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein-tyrosine kinase: R. Seger, et al.; J. Biol. Chem.
270, 28325 (1995),
Abstract;
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex: S. Kapas, et al.; Biochem. J.
305 (Pt2), 433 (1995),
Abstract;
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini: R.D. Duan & J.A. Williams; Am. J. Physiol.
267, G401 (1994),
Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem.
32, 2344 (1989),
Abstract;
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation: R.M. Lyall, et al.; J. Biol. Chem.
264, 14503 (1989),
Abstract;
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science
242, 933 (1988),
Abstract;
