Replaces Prod. #: ALX-270-130
A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).
Product Details
| Formula: | C10H6N2O3 |
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| MW: | 202.2 |
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| CAS: | 118409-58-8 |
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| Purity: | ≥99% |
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| Appearance: | Yellow-orange solid. |
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| Solubility: | Soluble in 100% ethanol or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Product is subject to oxidation. Make solutions fresh daily. |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro: G. Partik, et al.; J. Cancer Res. Clin. Oncol.
125, 379 (1999),
Abstract;
Inhibition of GTP-utilizing enzymes by tyrphostins: G. Wolbring, et al.; J. Biol. Chem.
269, 22470 (1994),
Abstract;
Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines: G. Bergamaschi, et al.; Leukemia
7, 2012 (1993),
Abstract;
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells: G.E. Bilder, et al.; Am. J. Physiol.
260, C721 (1991),
Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem.
32, 2344 (1989),
Abstract;
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science
242, 933 (1988),
Abstract;
