A potent and specific substrate analog PLA2 inhibitor (IC50=6.2 µM-porcine pancreatic PLA2). It inhibits human recombinant sPLA2 (IC50=13.7 µM) selectively over cPLA2. At 1 µM it completely blocked the myogenic response in perfused dog renal arcuate arteries.
Product Details
| Formula: | C25H52NO5P |
| |
| MW: | 477.7 |
| |
| Source: | Synthetic. |
| |
| CAS: | 96720-06-8 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | Colorless oil or waxy solid. |
| |
| Solubility: | Soluble in 100% ethanol. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W.C. Hope, et al.; Agents Actions
39, C39 (1993),
Abstract;
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries: K. Kauser, et al. ; Circulation Res.
68, 1154 (1991),
Abstract;
Full Text
