Replaces Prod. #: ALX-550-056
Selective GABAB receptor antagonist. Antagonizes the postsynaptic action of baclofen (Prod. No. BML-EA128).
Product Details
| Alternative Name: | (±)-3-Amino-2-(4-chlorophenyl)-propylphosphomic acid |
| |
| Formula: | C9H13ClNO3P |
| |
| MW: | 249.6 |
| |
| CAS: | 114012-12-3 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Identity: | Determined by 1H-NMR and MS. |
| |
| Appearance: | White solid. |
| |
| Solubility: | Soluble in water, methanol or DMSO. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | Ambient |
| |
| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Effects of taurine on depolarization-evoked release of amino acids from rat cortical synaptosomes: Y. Kamisaki, et al.; Brain Res.
627, 181 (1993),
Abstract;
gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor: G. Bonanno & M. Raiteri; J. Pharmacol. Exp. Ther.
265, 765 (1993),
Abstract;
A physiological role for GABAB receptors in the central nervous system: P. Dutar & R.A. Niccol; Nature
332, 156 (1988),
Abstract;
Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons: H. Hasuo & J.P. Gallagher; Neurosci. Lett.
86, 77 (1988),
Abstract;
Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex: G. Karlsson, et al.; Eur. J. Pharmacol.
148, 485 (1988),
Abstract;
Phaclofen: a peripheral and central baclofen antagonist: D.I. Kerr, et al.; Brain Res.
405, 150 (1987),
Abstract;
