Replaces Prod. #: ALX-480-087
A cell-permeable cGMP antagonist which is resistant to hydrolysis by cyclic nucleotide phosphodiesterases (Ki=0.5 µM). No metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No. ALX-480-072) or Rp-8-Br-cGMPS (Prod. No. BML-CN216)
Product Details
| Formula: | C16H14N5O6PS2Cl . Na |
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| MW: | 525.9 |
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| CAS: | 153660-04-9 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (25 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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461, 1 (2015),
Application(s): Cell Culture,
Abstract;
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action: R.H. Kramer & G.R. Tibbs ; J. Neurosci.
16, 1285 (1996),
Abstract;
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms: D.M. Gamm et al.; J Biol Chem
270, 27380 (1995),
Abstract;
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor: E. Butt et al.; Eur. J. Pharmacol.
269, 265 (1994),
Abstract;
