Replaces Prod. #: ALX-480-060
SQ 22536 is a cell-permeable adenylate cyclase inhibitor. It inhibits cAMP production induced by prostaglandin E1 in platelet lysates (IC50=82 µM) and in intact platelets (IC50=1 µM). It has been successfully employed as a probe for the involvement of adenylate cyclase in a variety of receptor systems including those for prostaglandins and neurotransmitters. ReducesPGE2-induced inhibition of O2- production.
Product Details
| Alternative Name: | 9-THF-Ade |
| |
| Formula: | C9H11N5O |
| |
| MW: | 205.2 |
| |
| Source: | Synthetic. |
| |
| CAS: | 17318-31-9 |
| |
| Purity: | ≥99% (TLC) |
| |
| Appearance: | White to off-white solid. |
| |
| Solubility: | Soluble in water (25mg/ml) or DMSO (50mM with warming). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stock solutions are stable for up to 3 months at -20°C. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney: B. Kalbe, et al.; Arch. Biochem. Biophys.
610, 8 (2016),
Application(s): Calcium imaging, HK-2 cells,
Abstract;
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling: P. Ivonnet, et al.; Br. J. Pharmacol.
172, 173 (2015),
Abstract;
Full Text
Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils: E. Talpain et al.; Br. J. Pharmacol.
114, 1459 (1995),
Abstract;
Relaxation and inhibition of contractile response to electrical field stimulation by Beraprost sodium in canine airway smooth muscle: J. Tamaoki et al.; Prostaglandins
45, 363 (1993),
Abstract;
cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons: B.A. Goldsmith & T.W. Abrams; PNAS
89, 11481 (1992),
Abstract;
Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons: W.X. Shi & B.S. Bunney; J. Neurosci.
12, 2433 (1992),
Abstract;
Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536: C. Lippe & C. Ardizzone; Comp. Biochem. Physiol. C.
99, 209 (1991),
Abstract;
Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536): E. Fabbri et al.; J. Enzyme. Inhib.
5, 87 (1991),
Abstract;
Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase: B.A. Goldsmith & T.W. Abrams; PNAS
88, 9021 (1991),
Abstract;
Adenylate cyclase system is essential for long-term facilitation at the crayfish neuromuscular junction: D. Dixon et al.; J. Neurosci.
9, 4246 (1989),
Abstract;
Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives: D. Harris et al.; J. Cyclic Nucleotide Res.
5, 125 (1979),
Abstract;
