Replaces Prod. #: ALX-550-346
PK-11195 is a ligand of the mitochondrial benzodiazepine receptor and selective antagonist of benzodiazepine. It facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.
Product Details
| Formula: | C21H21CIN2O |
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| MW: | 352.9 |
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| CAS: | 85532-75-8 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White crystalline powder. |
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| Solubility: | Soluble in 100% ethanol, methanol, dichlormethane or DMSO. Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection: T. Hirsch, et al.; Exp. Cell. Res.
241, 426 (1998),
Abstract;
Differential binding properties of the peripheral-type benzodiazepine ligands [3H]PK 11195 and [3H]Ro 5-4864 in trout and mouse brain membranes: A.J. Eshleman & T.F. Murray; J. Neurochem.
53, 494 (1989),
Abstract;
Pharmacokinetics and effects on exercise heart rate of PK 11195 (52028 RP), an antagonist of peripheral benzodiazepine receptors, in healthy volunteers: A. Ferry, et al.; Fundam. Clin. Pharmacol.
3, 383 (1989),
Abstract;
Photoaffinity labeling of peripheral-type benzodiazepine-binding sites: A. Doble, et al.; Mol. Pharmacol.
31, 42 (1987),
Abstract;
Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination: A. Doble, et al.; Eur. J. Pharmacol.
119, 153 (1985),
Abstract;
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies: G. Le Fur, et al.; Life Sci.
33, 449 (1983),
Abstract;
